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1.
Chinese Journal of Traumatology ; (6): 306-310, 2021.
Article in English | WPRIM | ID: wpr-888425

ABSTRACT

A 19-year-old male patient who suffered from sudden and repeated multiple organ dysfunction syndrome one month after the bar removal procedure of Nuss surgery for pectus excavatum was admitted to our department. With organ function supportive treatment, the etiology was finally identified to be a bone spur located at the inner border of the left costa due to repeated friction between the implanted steel bar and the rib, which damaged the heart repeatedly and induced the consequent acute cardiac tamponade. After operation, the patient was successfully managed and discharged. Follow-ups till three years indicated a good recovery.

2.
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery ; (12): 900-906, 2020.
Article in Chinese | WPRIM | ID: wpr-824990

ABSTRACT

@#Objective    To explore the surgical design and efficacy of novel modified Nuss procedure for pectus excavatum (PE). Methods    We retrospectively analyzed the clinical data of 903 patients with PE who were treated by the new kind of steel bar and the novel modified Nuss procedure. There were 716 males and 187 females at mean age of 2-45 (12.1±6.8) years. Preoperative chest CT scans Haller index (HI) was 3.1-15.2 (4.6±1.3), with 38 patients of mild PE (HI<3.2), 302 patients of moderate PE (HI 3.2-3.5), 521 patients of severe PE (HI 3.6-6.0), and 42 patients of extremely severe PE (HI>6.0). The operative time, operative blood loss, hospital stay time as well as postoperative complications were reviewed and analyzed. Results    All of the 903 patients successfully completed the surgery. The mean operative time was 20-45 (25.2±2.6) min for primary PE and that for special type of PE (including recurring PE, PE patients after heart disease operation and those corrected by 2 bars) was 48-150 (63.5±28.1) min. Blood loss was less than 10 mL for primary PE and 15-50 (23.5±5.5) mL for special type of PE. Postoperative hospital stay was 3-15 (4.5±1.6) d. A total of 845 patients (93.6%) required 1 steel bar insertion, 58 patients (6.4%) required 2 steel bars. Postoperative evaluation of the surgery outcomes revealed the following: excellent in 805 patients, good in 84 patients, fair in 14 patients and poor in 0. The good quality rate was 98.4%. Conclusion    Novel modified Nuss procedure can simplify and optimize the surgical design with good short and mid-term effects.

3.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 645-648, 2019.
Article in Chinese | WPRIM | ID: wpr-801350

ABSTRACT

Objective@#To evaluate the efficacy of using sternal suspension technique in correcting pectus excavatum after open repair of congenital heart disease and improve the safety of this technique.@*Methods@#A retrospective study was conducted for 8 cases of pectus excavatum treated with sternal suspension procedure after open repair of congenital heart disease from October 2005 to October 2018 in our institution, 5 males and 3 females. The median age of patients was 5.75 years (range 3.75-12.33 years) and the median Haller index was 4.20(range 3.60-5.19). All patients underwent cardiac ultrasound and chest CT scan to evaluate the severity retrosternal adhesions.@*Results@#All patients underwent the sternal suspension procedure successfully with a median operation time 55 min (range 30-230 min) and a median blood loss of 2 ml (range 2-120 ml). There was one patient suffered pneumothorax after operation. The patients were followed up for 4 months to 13 years with an excellent and good outcome.@*Conclusion@#Sternal suspension technique is a safe and effective procedure for pectus excavatum. To improve the security and reduce the incidence of cardiac injury, sternal suspension technique is a promising alternative for pectus patients with severe adhesion after open repair of congenital heart disease.

4.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 641-644, 2019.
Article in Chinese | WPRIM | ID: wpr-801349

ABSTRACT

Objective@#To provide data references for Nuss procedure biomechanics research, and to understand morphological pathological changes in children with pectus excavatum.@*Methods@#A retrospective study was conducted for 434 cases of pectus excavatum from January 2009 to December 2015 in our institution. The anterior rib width(RW), anterior intercostal space width(IS) and thickness of the rib in the middle(RT) on the right side of 3-7 ribs had been measured in each patient. The widths were compared between the IS of children with pectus excavatum and the bar which currently used in clinic. The measurement indexes were compared between healthy children and children with pectus excavatum.@*Results@#The IS of prepubertal children with pectus excavatum was less than the width of bar which currently used in clinic (12.7 mm). Children with pectus excavatum compared with healthy children, the IS from 4 to 6 and the 5th RW of children with pectus excavatum were less than healthy children (P<0.05), the 3rd and 4th RT were greater than healthy children (P<0.05).@*Conclusion@#The measured values will be useful for the improvement of pectus bar and Nuss procedure biomechanics research. By morphology contrast, it reflects the pectus excavatum deformity has some restriction in thoracic development and the cardiopulmonary function.

5.
Yeungnam University Journal of Medicine ; : 260-264, 2019.
Article in English | WPRIM | ID: wpr-785322

ABSTRACT

Pectus excavatum (PE) is known as one of the most common congenital deformities of the anterior chest wall. The Nuss procedure is an effective surgical therapy to correct PE. Here, we report a case of recurrent cardiac tamponade due to hemopericardium that occurred after 16 months following the Nuss procedure. The cause of recurrent hemopericardium was thought to be local, repetitive irritation of the pericardium by the Nuss steel bar. We should keep in mind that this serious complication can occur after the Nuss procedure, even in the late phase.


Subject(s)
Cardiac Tamponade , Congenital Abnormalities , Funnel Chest , Pericardial Effusion , Pericardium , Steel , Thoracic Wall
6.
International Journal of Pediatrics ; (6): 887-890, 2019.
Article in Chinese | WPRIM | ID: wpr-800667

ABSTRACT

Pectus excavatum is the most common congenital deformity of the chest wall in children.Currently, surgery remains to be the most effective treatment available for this disease.The Nuss procedure has become the most widely used technique in clinical work since 1998.However, the optimal operation time remains controversial, no consensus exists among surgeons.Mostly, surgeons from western countries believe it′s best to repair the deformity around the time of puberty, while Chinese surgeons prefer to perform the surgery earlier, mainly at three to six years old, or around school age.Hence, this review was carried out to summarize the surgical results and postoperative complications of Nuss procedure among different age groups, purposed to offer a reference for the rational decision of pediatric surgeons.

7.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 645-648, 2019.
Article in Chinese | WPRIM | ID: wpr-824864

ABSTRACT

Objective To evaluate the efficacy of using sternal suspension technique in correcting pectus excavatum after open repair of congenital heart disease and improve the safety of this technique.Methods A retrospective study was conducted for 8 cases of pectus excavatum treated with sternal suspension procedure after open repair of congenital heart disease from October 2005 to October 2018 in our institution,5 males and 3 females.The median age of patients was 5.75 years (range 3.75-12.33 years) and the median Haller index was 4.20 (range 3.60-5.19).All patients underwent cardiac ultrasound and chest CT scan to evaluate the severity retrosternal adhesions.Results All patients underwent the sternal suspension procedure successfully with a median operation time 55 min (range 30-230 min) and a median blood loss of 2 ml (range 2-120 ml).There was one patient suffered pneumothorax after operation.The patients were followed up for4 months to 13 years with an excellent and good outcome.Conclusion Sternal suspension technique is a safe and effective procedure for pectus excavatum.To improve the security and reduce the incidence of cardiac injury,sternal suspension technique is a promising alternative for pectus patients with severe adhesion after open repair of congenital heart disease.

8.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 641-644, 2019.
Article in Chinese | WPRIM | ID: wpr-824863

ABSTRACT

Objective To provide data references for Nuss procedure biomechanics research,and to understand morphological pathological changes in children with pectus excavatum.Methods A retrospective study was conducted for 434 cases of pectus excavatum from January 2009 to December 2015 in our institution.The anterior rib width(RW),anterior intercostal space width(IS) and thickness of the rib in the middle(RT) on the right side of 3-7 ribs had been measured in each patient.The widths were compared between the IS of children with pectus excavatum and the bar which currently used in clinic.The measurement indexes were compared between healthy children and children with pectus excavatum.Results The IS of prepubertal children with pectus excavatum was less than the width of bar which currently used in clinic (12.7 mm).Children with pectus excavatum compared with healthy children,the IS from 4 to 6 and the 5th RW of children with pectus excavatum were less than healthy children (P < 0.05),the 3rd and 4th RT were greater than healthy children (P < 0.05).Conclusion The measured values will be useful for the improvement of pectus bar and Nuss procedure biomechanics research.By morphology contrast,it reflects the pectus excavatum deformity has some restriction in thoracic development and the cardiopulmonary function.

9.
International Journal of Pediatrics ; (6): 887-890, 2019.
Article in Chinese | WPRIM | ID: wpr-823463

ABSTRACT

Pectus excavatum is the most common congenital deformity of the chest wall in children.Currently,surgery remains to be the most effective treatment available for this disease.The Nuss procedure has become the most widely used technique in clinical work since 1998.However,the optimal operation time remains controversial,no consensus exists among surgeons.Mostly,surgeons from western countries believe it's best to repair the deformity around the time of puberty,while Chinese surgeons prefer to perform the surgery earlier,mainly at three to six years old,or around school age.Hence,this review was carried out to summarize the surgical results and postoperative complications of Nuss procedure among different age groups,purposed to offer a reference for the rational decision of pediatric surgeons.

10.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 494-496, 2019.
Article in Chinese | WPRIM | ID: wpr-756384

ABSTRACT

Objective To evaluate the thoracic status of patients with funnel chest by quantitative evaluation of chest Xray,and to explore the effect of Nuss surgery.Methods From October 2006 to February 2011,according to the inclusion criteria,there were 47 cases enrolled our group at last,then divided the cases into 3 groups,including pre-operative of Nuss procedure,recent post-bar removal and further post-bar removal.We measured data on chest radiography and statistical analysis,including the maximal distance of the outer boundary of each rib pairs (C,from the 1 st pair to the 9th),the distance between lung apex to the costophrenic angle (H) and the distance between the two costophrenic angles(W).Results All the 47 cases completed the Nuss procedure and Nuss bar removal safely and effectively.All the patients were followed up from 30 to 36 months,without recurrence or long-term complications.Three groups of thoracic data showed an increasing trend,recent post-bar removal and further post-bar removal compared with the same age normal children,the thoracic data of the Nuss bar position were shortened.With the prolongation of time after Nuss bar removal,thoracic data gradually approaching normal.Conclusion We can evaluate the level of pectus excavatum and effect of Nuss procedure through measuring the chest wall data.The chest wall of post-bar removal was significantly improvement compared to the cases of pre-Nuss procedure.There is some restrictions on the thoracic by the Nuss bar.we learn that the limitation of thoracic can be improve after some time.

11.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 349-353, 2019.
Article in Chinese | WPRIM | ID: wpr-756358

ABSTRACT

Objective To explore the clinical efficacy of modified twin-incision thoracoscopic Nuss procedure for pediat-ric pectus excavatum.Methods A retrospective review was performed for the clinical data of 50 cases of pectus excavatum from July 2017 to May 2016.There were 30 boys and 20 girls with an average age of 6.5( 3.3-16.0) years.All of them un-derwent modified twin-incision thoracoscopic Nuss procedure.Average haller index was 3.0-6.9.Pectus excavatum 35 cases , asymmetric pectus excavatum 15 cases.Results 50 cases procedures were successfully completed .Operative duration was( 60 ±15) min, intraoperative blood loss( 5 ±2) ml, without serious complications during and after operation, and the average postoperative hospitalization stay(6 ±1) days, the postoperative effect was successfully, during follow-up from 7 months to 17months after the operation.Conclusion Modified twin-incision thoracoscopic Nuss procedure with is both safe and effective for pediatric pectus excavatum.With the advantages of shorter operative duration,mini-invasiveness,fewer complications and excellent cosmetics,it is worthy of wider popularization.

12.
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery ; (12): 213-217, 2018.
Article in Chinese | WPRIM | ID: wpr-749801

ABSTRACT

@#Objective    To explore the feasibility and efficacy in therapy of pectus excavatum using novel modified Nuss procedure after congenital heart disease (CHD) operation. Methods    Thirty-six children (including 22 males and 14 females with an average age of 4.5±2.2 years ranging 2.8-18.0 years) with pectus excavatum after CHD operation from January 2011 to March 2015 were selected as an observation group. Thirty-eight pectus excavatum children (including 24 males and 14 females with an average age of 4.0±2.5 years ranging 2.8-20.0 years) without CHD from July to September 2013 were selected as a control group. The novel modified Nuss procedure was performed on the patients in both groups. The operation time, intraoperative blood loss, hospital stay as well as postoperative complications between two groups were reviewed and analyzed. Results    In the observation group, the operation time was 50-72 (60.50±3.60) min and hospital stay was 4-6 (4.41±0.80) d. Meanwhile, the intraoperative blood loss was 5-10 (5.82±0.35) ml. In the control group, the operation time was 12-45 (20.15±0.68) min, hospital stay was 4-7 (4.61±0.63) d and the intraoperative blood loss was 3-8 (4.62±0.28) ml. The operation time was significantly longer in the observation group than that in the control group (P<0.05). But there was no significant difference in intraoperative blood loss or hospital stay between the two groups (P>0.05). No cardiac rupture happened in the two groups. Conclusion    The novel modified Nuss procedure is safe and feasible for pectus excavatum after CHD operation with optimal outcomes.

13.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 491-494, 2018.
Article in Chinese | WPRIM | ID: wpr-711820

ABSTRACT

Objective By measuring the thoracic cage index with chest X-ray film in 3-17 years old healthy children,analyzing the bivariate correlations with age,to provide the reference data for evaluating and following up of chest wall deformity.Methods A retrospective study was conducted for 450 cases of health physical examination from May 2013 to March 2016 in our institution.The anterior intercostal space width(IS),the anterior rib width(RW),and thickness of the rib in the middle(RT) on the right side of 3-7 ribs have been measured in each patient.Statistical describing for each measurement index has been made,and Pearson correlation analysis was used to analyze the correlation between measurement values and ages.Results Each measurement index is strong positive correlated with age (0.6 < r < 0.8,P < 0.05).Conclusion The anterior intercostal space width,the anterior rib width and the thickness of the ribs in the middle have a growing trend with age in children.It is indeed a useful way to measure thoracic cage data by using the chest X-ray film quantitative evaluation method.The measured values can be used as reference indexes.

14.
Chinese Journal of Thoracic and Cardiovascular Surgery ; (12): 733-737, 2017.
Article in Chinese | WPRIM | ID: wpr-665887

ABSTRACT

Objective To study the influence of the minimal invasive Nuss procedure on the pulmonary function of post-operative pectus excavatum patients. Methods Conduct retrospective analysis on the data from 676 pectus excavatum patients who were treated by the minimal invasive Nuss procedure from August 2006 to November 2014. Wherein 182 cases have com-plete preoperative and postoperative pulmonary-function data of one year, three years. These cases were divided into 3 groups according to the age, namely, children group( from 6 to 12 years old, 34 cases) , adolescents group( from 13 to 18 years old, 80 cases) , adults group( above 18 years old, 68 cases) , among which there were 71 cases with pulmonary function data of 1 year after removal of steel plate, they were divided into 3 groups in the same way,namely, children group(20 cases), adoles-cents group(22 cases), adults group(29 cases) . To compare and analyze the pulmonary function indicatrix of patients with dif-ferent ages in preoperative stage, 1 year, 3 years postoperative stages and 1 year after dismantling the steel plate stage, and to investigate the influence of the minimal invasive Nuss procedure on the postoperative lung function. Results The pulmonary function indicatrix in preoperative stage, 1 year, 3 years postoperative stages of the children group did not have significant difference(P>0. 05); the FVC, FEV1 indicatrix of adolescents and adults groups declined after operation in 1 year and 3 years compared with the preoperative stage(P<0. 05), FEF 25% -75%, FEF 50%, FEF75% were improved after operation in 1 year and 3 years compared with the preoperative stage(P<0. 05);the pulmonary function indicatrix of three age groups in the 1 year after dismantling the steel plate stage had all improved, in which the pulmonary function indicatrix of the children group improves most significantly(P<0. 05). Conclusion After the minimal invasive Nuss procedure before the plate dis-mantling process, the pulmonary function of children patients remains to be similar. Partial ventilatory function was damaged in the adolescents and adults patients. After the plate dismantling process, the pulmonary function indicatrix of each age group hasimproved in different degrees. Improvement effect is the most significant in patients below the age of 12.

15.
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1321-1323, 2015.
Article in Chinese | WPRIM | ID: wpr-471077

ABSTRACT

Objective To explore the operation method and curative effect of small incision minimally invasivepectus excavatum with non thoracoscopic xiphoid.Methods Clinical data of 12 cases with small incision minimally invasive pectus excavatum non thoracoscopic subxiphoid were retrospectively analyzed The index operation time,operation of the surgical bleeding,postoperative complications,postoperative hospitalization time and curative effect evaluation etc,were analyzed.Results 12 patients were successfully completed surgery.The time of operation was (35 ± 8)min;intraoperative blood loss was 5-20 mL,average 10mL;1 patients had pneumothorax postoperative complications;postoperative hospitalization time 3-7day,average 5days;postoperative effect evaluation were excellent in 12 cases.Conclusion Non thoracoscope assisted small incision under xiphoid minimally invasive pectus excavatum surgery is minimally invasive,beautiful appearance,reliable effect and other advantages,and can simplify the operation steps for primary hospital.

16.
Chinese Journal of Minimally Invasive Surgery ; (12): 752-754,758, 2015.
Article in Chinese | WPRIM | ID: wpr-602508

ABSTRACT

[Summary] Pectus excavatum ( PE ) is a posterior intrusion of the chest wall into the thoracic cavity . Although the physiological and psychological consequences vary , for a large number of patients the lesions are troublesome enough that they need corrective surgery .The minimally invasive repair of pectus excavatum ( Nuss procedure ) has been performed safely , effectively , and extensively .The current situations and progresses associated with the Nuss procedure were reviewed .

17.
Ann Card Anaesth ; 2013 Jul; 16(3): 205-208
Article in English | IMSEAR | ID: sea-147266

ABSTRACT

Pectus excavatum is a chest wall deformity that produces significant cardiopulmonary disability and is typically seen in younger patients. Minimally invasive repair of pectus excavatum or Nuss procedure has become a widely accepted technique for adult and pediatric patients. Although it is carried out through a thoracoscopic approach, the procedure is associated with a number of potential intraoperative and post-operative complications. We present a case of cardiac perforation requiring emergent cardiopulmonary bypass in a 29-year-old male with Marfan syndrome and previous mitral valve repair undergoing a Nuss procedure for pectus excavatum. This case illustrates the importance of vigilance and preparation by the surgeons, anesthesia providers as well as the institution to be prepared with resources to handle the possible complications. This includes available cardiac surgical backup, perfusionist support and adequate blood product availability.


Subject(s)
Adult , Cardiopulmonary Bypass , Emergencies , Funnel Chest/complications , Funnel Chest/surgery , Heart Atria/injuries , Heart Injuries/injuries , Heart Injuries/surgery , Humans , Intraoperative Complications/therapy , Male , Marfan Syndrome/complications
18.
Rev. chil. pediatr ; 84(2): 166-176, abr. 2013. ilus, tab
Article in Spanish | LILACS | ID: lil-687172

ABSTRACT

Antecedentes: El Pectus excatavum es la deformidad congénita más frecuente de la pared anterior del tórax. Esta condición es abordada quirúrgicamente por causas estéticas y/o funcionales. La técnica quirúrgica de Nuss destaca por tener mejores resultados estéticos y menor grado de traumatismo y complicaciones en comparación con otras técnicas. El objetivo del presente estudio fue conocer el cambio en la calidad de vida y el grado de satisfacción post operatoria, en los pacientes pediátricos y sus padres, operados mediante técnica de Nuss. Pacientes y Método: Se realizó un estudio descriptivo, de cohorte única, sometiendo a los pacientes y a sus padres a evaluación de la calidad de vida y satisfacción post operatoria mediante el cuestionario de Nuss y Krasopoulos, siendo los datos analizados, en base al n de la muestra, mediante mediana, rangos intercuartiles y t-student, con p < 0,05, según prueba pareada de Wilcoxon. Resultados: Se registraron 31 pacientes operados de Pectus excatavum, siendo la gran mayoría de causa tanto estética como funcional. Tanto en el cuestionario de Nuss, como en el de Krasopoulos, todas las respuestas a preguntas sobre diferencias pre cirugía y post cirugía fueron estadísticamente significativas, con un t-student de p < 0,05. Conclusión: La corrección del Pectus excatavum mediante técnica de Nuss ha mostrado un efecto positivo, tanto en la esfera física, como biopsicosocial de los pacientes al corregir su deformidad, lo que se ve claramente reflejado en una mejora de la autoestima y en la percepción de su estado de salud, por parte de los pacientes.


Pectus excatavum is the most common congenital deformity of the anterior wall of the chest. This condition is approached surgically for cosmetic and/or functional purposes. The Nuss procedure is a minimally-invasive procedure with excellent cosmetic outcomes and is less traumatic than other techniques. This study was conducted to determine pediatric patients and their parents' postoperative satisfaction and changes in quality of life after the Nuss technique. Patients and Method: A descriptive and single cohort study was performed subjecting patients and their parents to evaluate their quality of life and postoperative satisfaction using the Nuss and Krasopoulos questionnaires. The data was analyzed based on sample of n, median, interquartile ranges and t-student test, with p <0.05, according to paired-sample Wilcoxon test. Results: 31 patients were operated on for Pectus excatavum; most of the patients required operation for aesthetics and functional reasons. All the answers to questions in both questionnaires, Nuss and Krasopoulos, regarding differences between pre surgery and post-surgery were statistically significant, with p < 0.05 using t-student values. Conclusion: The correction of Pectus excatavum using the Nuss procedure has shown a positive effect physically and biopsy-chosocially on patients to correct the deformity, resulting in improved patients' self-esteem and perception of their health.


Subject(s)
Humans , Male , Adolescent , Female , Child , Patient Satisfaction , Minimally Invasive Surgical Procedures/methods , Quality of Life , Funnel Chest/surgery , Postoperative Period , Surveys and Questionnaires
19.
Journal of Central South University(Medical Sciences) ; (12): 848-852, 2013.
Article in Chinese | WPRIM | ID: wpr-438688

ABSTRACT

Objective:To summarize the curative effect, safety and experience of non-thoracoscopic modiifed Nuss procedure for correction of pectus excavatum (PE). Methods:From January 2007 to December 2011, 267 cases of PE patients were selected in our hospital. Among them 85 were treated by thoracoscopic minimally invasive modified Nuss Procedure and 182 by non-thoracoscopic procedure. The operation time, blood loss during operation, length of postoperative hospital stay and effect of treatment were compared retrospectively. Results:All the 267 patients finished the repair procedure smoothly. The non-thoracoscopic group had advantage in terms of operative time (22.5 min vs 35.1 min, P0.05). hTere were no deaths. Conclusion:Non-thoracoscopic minimally invasive modified Nuss procedure is as safe and effective as thoracoscopic Nuss procedure. With advantages of simpliifed operation procedure and shorter operation time, it is easier in practice.

20.
The Korean Journal of Pain ; : 267-271, 2012.
Article in English | WPRIM | ID: wpr-165126

ABSTRACT

The Nuss procedure for the correction of Pectus Excavatum (PE) is associated with intense postoperative pain. Our strategy to control early postoperative pain is to combine epidural with intravenous analgesia. Our aim was to analyse our pain control strategy by reviewing all the PE cases treated at our institution. Sixty consecutive patients, aged between 12 and 26 years old, received the PE operation at our institution from January, 2007 to September, 2010. The median age was 16 (12-27) with a male/female ratio of about 7/1. An epidural catheter was employed in all the cases, with 38 patients (63%) requiring additional drugs to control pain, which remained in place for 74 hours (72-96). The pain score was higher in male patients, but lower in those younger than 16 years old. Moreover, patients that consumed benzodiazepines had a significant decrease in cumulative opioid intake (P = 0.0408). Both gender and age had an impact on pain control, while we noticed a synergistic effect between opiates and tranquillizers.


Subject(s)
Aged , Humans , Male , Analgesia , Anxiety , Benzodiazepines , Catheters , Funnel Chest , Hypogonadism , Mitochondrial Diseases , Ophthalmoplegia , Pain, Postoperative
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